On October 7th, 2009 the Nobel Committee announced three structural biologists would share the 2009 Nobel Prize in Chemistry for studies of the the
ribosome. The ribosome is the machine in your cells that accurately and efficiently decodes the genetic information stored in your genome and synthesizes the corresponding polypeptide chain one amino acid at a time in the process of translation. Venkatraman Ramakrishnan of the M.R.C. Laboratory of Molecular Biology in Cambridge, England; Thomas A. Steitz of Yale University; and Ada E. Yonath of the Weizmann Institute of Science in Rehovot, Israel share the prize for the first atomic-resolution structures of the two subunits that come together to form an active ribosome. These structures are considered landmarks for the fact they showed clearly the major contributions to decoding and peptide bond synthesis come from RNA and not protein, as well as for the sheer size of the structures determined. These structures represent tour-de-force efforts in understanding fundamental processes in every organism on earth and will have direct impacts on how we fight pathogenic bacteria in the immediate future. Shown are both subunits of the ribosome, as well as that bind in the complex during the process of translation. (more...)
November 2024: How To Find A Structure is a new guide to finding an empirical model for a protein of interest, choosing which empirical structure is best, and getting an AlphaFold-predicted structure when no empirical structures are available.
March 2024: Professors are using Proteopedia for class projects in Brazil, Czech Republic, France, and various states in the USA. See the updated Adoptions in College and University Classes.
What happens if a SARS-CoV-2 coronavirus enters your lung? See a clear explanation at Lifecycle of SARS-CoV-2
5,000 users!! On December 4, 2021, the number of Proteopedia users went over 5,000. The 5,000th user is from Juniata College, Huntingdon, Pennsylvania, US
AlphaFold protein structure predictions - a step change for biology, an electronic talk by EBI staff for students and early career researchers via FEBS Junior Sections, Oct. 26, 2021, 19:00 CEST. Announcement. Registration.
A practical guide to teaching with Proteopedia [1]
June, 2016: Proteopedia uses the Biological Assemblies from PDBe as the default scenes for all PDB entry pages. Thus, based on the curation by EBI (host for PDBe) the most biologically significant structure is shown.
June, 2015: Award Ceremony for the the Proteopedia Award at the ICSG2015 - Deep Sequencing Meets Structural Biology, awarded on 10-Jun-2015 at the Weizmann Institute of Science
December, 2014, Talking about Proteopedia on 12/04/14-12/06/14, a live online talk organised by DivCHED CCCE: Committee on Computers in Chemical Education
October, 2014 Course in Spanish/English on Proteopedia and its uses to study, display and teach macromolecules.
↑Castro C, Johnson RJ, Kieffer B, Means JA, Taylor A, Telford J, Thompson LK, Sussman JL, Prilusky J, Theis K. A practical guide to teaching with Proteopedia. Biochem Mol Biol Educ. 2021 Jun 3. doi: 10.1002/bmb.21548. PMID:34080750 doi:http://dx.doi.org/10.1002/bmb.21548
