TIR domain-containing adapter protein

TIR domain-containing adapter protein or Toll/Interleukin-1 receptor domain-containing adapter protein (TIRAP) is one of 5 proteins involved in the Toll interleukin 1 receptor signaling pathway of the immune system. The 5 adaptor proteins are: MyD88, MAL, TRIF, TRAM and SARM. The TIR domain is found in Toll-like receptors and in adaptor proteins. The domain containing 135 to 160 amino acids, consists of 3 boxes of conserved residues. The TIR domain is involved in the interaction between Toll-like receptors and the adaptor protein. TIRAP activates NF-kB, MAPK1, MAPK3 and JNK which results in the inflammatory response.

spinqualitylabelsall models MAL adaptor protein TIR domain complex with dithiothreitol (PDB code 3ub2) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of TIR domain-containing adapter protein3D Structures of TIR domain-containing adapter protein

Updated on 25-April-2022

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• TIRAP or Toll/interleukin-1 receptor domain-containing adapter protein or MAL
  • 2y92, 3ub2, 4fz5, 4lqd – hTIRAP TIR domain 81-221 - human
    
  • 5uzb – hMAL TIR domain - Cryo EM
    
  • 3ub3, 3ub4 – hMAL TIR domain (mutant)
    
  • 2m1w, 2m1x, 2ndh – hMAL TIR domain (mutant) - NMR
    
  • 2m63 – hMAL N-terminal domain - NMR
    
  • 5t7q – hMAL residues 15-35 - NMR
    
• MyD88 or myeloid differentiation primary response protein MyD88; Domains – death 12-163; TIR 157-296
  • 4dom, 4eo7, 7beq, 7ber, 7l6w – hMyD88 TIR domain 157-296
    
  • 2z5v – hMyD88 TIR domain - NMR
    
  • 6i3n – hMyD88 death domain – Cryo EM
    
  • 3mop – hMyD88 death domain + IRAK-2 + IRAK-4
    
• TRIF
  • 4c0m – hTRIF N-terminal domain
    
  • 4bsx – hTRIF N-terminal domain (mutant)
    
• TcpB
  • 4lqc, 4c7m – TcpB TIR domain (mutant) – Brucella melitensis