Arsenate reductase

Function

Arsenate reductase or glutaredoxin arsenate reductase (AsR) catalyzes the conversion of arsenate (As V) and glutaredoxin to arsenite (As III) and glutaredoxin disulfide.^[1]

Relevance

AsR is part of the arsenic detoxification pathway.

Structural highlights

The AsR active site contains a . (PDB entry 1j9b).^[2]

3D structures of arsenate reductase

Arsenate reductase 3D structures

Structure of arsenate reductase complex with arsenate, thiarsahydroxy-cysteine, sulfate and Cs+ ion (dark purple) (PDB entry 1j9b)

Drag the structure with the mouse to rotate

ReferencesReferences

↑ Holmgren A, Aslund F. Glutaredoxin. Methods Enzymol. 1995;252:283-92. PMID:7476363
↑ Martin P, DeMel S, Shi J, Gladysheva T, Gatti DL, Rosen BP, Edwards BF. Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme. Structure. 2001 Nov;9(11):1071-81. PMID:11709171

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Michal Harel, Alexander Berchansky

[1] Holmgren A, Aslund F. Glutaredoxin. Methods Enzymol. 1995;252:283-92. PMID:7476363

[2] Martin P, DeMel S, Shi J, Gladysheva T, Gatti DL, Rosen BP, Edwards BF. Insights into the structure, solvation, and mechanism of ArsC arsenate reductase, a novel arsenic detoxification enzyme. Structure. 2001 Nov;9(11):1071-81. PMID:11709171

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Arsenate reductase

Contents

Function

Relevance

Structural highlights

3D structures of arsenate reductase

ReferencesReferences

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Arsenate reductase

Function

Relevance

Structural highlights

3D structures of arsenate reductase

ReferencesReferences

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