8xwf

Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)

Structural highlights

8xwf is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.65Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

CXCL3_HUMAN Ligand for CXCR2 (By similarity). Has chemotactic activity for neutrophils. May play a role in inflammation and exert its effects on endothelial cells in an autocrine fashion. In vitro, the processed form GRO-gamma(5-73) shows a fivefold higher chemotactic activity for neutrophilic granulocytes.^[1]

References

↑ Wuyts A, Govaerts C, Struyf S, Lenaerts JP, Put W, Conings R, Proost P, Van Damme J. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. Eur J Biochem. 1999 Mar;260(2):421-9. PMID:10095777

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Wuyts A, Govaerts C, Struyf S, Lenaerts JP, Put W, Conings R, Proost P, Van Damme J. Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms. Eur J Biochem. 1999 Mar;260(2):421-9. PMID:10095777

[1]

8xwf

Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

8xwf

Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)Structure of CXCR2 bound to CXCL3 (Ligand-receptor focused map)

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search