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Solution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regionsSolution structure of TLR5 transmembrane and cytoplasmic juxtamembrane regions
Structural highlights
DiseaseTLR5_HUMAN Disease susceptibility is associated with variations affecting the gene represented in this entry. FunctionTLR5_HUMAN Participates in the innate immune response to microbial agents. Mediates detection of bacterial flagellins. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.[1] See AlsoReferences
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