7rrl

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Alternate Crystal Form of Human Malate Dehydrogenase IAlternate Crystal Form of Human Malate Dehydrogenase I

Structural highlights

7rrl is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.05Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

MDHC_HUMAN The disease is caused by variants affecting the gene represented in this entry.

Function

MDHC_HUMAN Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237).[1] [2]

See Also

References

  1. ↑ Friedrich CA, Ferrell RE, Siciliano MJ, Kitto GB. Biochemical and genetic identity of alpha-keto acid reductase and cytoplasmic malate dehydrogenase from human erythrocytes. Ann Hum Genet. 1988 Jan;52(1):25-37. doi: 10.1111/j.1469-1809.1988.tb01075.x. PMID:3052244 doi:http://dx.doi.org/10.1111/j.1469-1809.1988.tb01075.x
  2. ↑ Broeks MH, Shamseldin HE, Alhashem A, Hashem M, Abdulwahab F, Alshedi T, Alobaid I, Zwartkruis F, Westland D, Fuchs S, Verhoeven-Duif NM, Jans JJM, Alkuraya FS. MDH1 deficiency is a metabolic disorder of the malate-aspartate shuttle associated with early onset severe encephalopathy. Hum Genet. 2019 Dec;138(11-12):1247-1257. doi: 10.1007/s00439-019-02063-z. Epub, 2019 Sep 19. PMID:31538237 doi:http://dx.doi.org/10.1007/s00439-019-02063-z

7rrl, resolution 2.05Å

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OCA
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