6z4u

X-ray Crystallographic Structure of Orf9b from SARS-CoV-2X-ray Crystallographic Structure of Orf9b from SARS-CoV-2

Structural highlights

6z4u is a 2 chain structure with sequence from Severe acute respiratory syndrome coronavirus 2. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.95Å
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ORF9B_SARS2 Plays a role in inhibiting the host innate immune response by targeting the mitochondrial-associated innate immune response. Acts by binding to host TOMM70, inhibiting its binding to HSP90AB1 thereby disrupting the interferon activation pathway.^[1] ^[2]

References

↑ Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC. SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. Cell Mol Immunol. 2020 Sep;17(9):998-1000. doi: 10.1038/s41423-020-0514-8. Epub, 2020 Jul 29. PMID:32728199 doi:http://dx.doi.org/10.1038/s41423-020-0514-8
↑ Brandherm L, Kobas AM, Klohn M, Bruggemann Y, Pfaender S, Rassow J, Kreimendahl S. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90. Int J Mol Sci. 2021 Aug 26;22(17). pii: ijms22179233. doi: 10.3390/ijms22179233. PMID:34502139 doi:http://dx.doi.org/10.3390/ijms22179233

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OCA

[1] Jiang HW, Zhang HN, Meng QF, Xie J, Li Y, Chen H, Zheng YX, Wang XN, Qi H, Zhang J, Wang PH, Han ZG, Tao SC. SARS-CoV-2 Orf9b suppresses type I interferon responses by targeting TOM70. Cell Mol Immunol. 2020 Sep;17(9):998-1000. doi: 10.1038/s41423-020-0514-8. Epub, 2020 Jul 29. PMID:32728199 doi:http://dx.doi.org/10.1038/s41423-020-0514-8

[2] Brandherm L, Kobas AM, Klohn M, Bruggemann Y, Pfaender S, Rassow J, Kreimendahl S. Phosphorylation of SARS-CoV-2 Orf9b Regulates Its Targeting to Two Binding Sites in TOM70 and Recruitment of Hsp90. Int J Mol Sci. 2021 Aug 26;22(17). pii: ijms22179233. doi: 10.3390/ijms22179233. PMID:34502139 doi:http://dx.doi.org/10.3390/ijms22179233

[1]

[2]

6z4u

X-ray Crystallographic Structure of Orf9b from SARS-CoV-2X-ray Crystallographic Structure of Orf9b from SARS-CoV-2

Structural highlights

Function

References

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6z4u

X-ray Crystallographic Structure of Orf9b from SARS-CoV-2X-ray Crystallographic Structure of Orf9b from SARS-CoV-2

Structural highlights

Function

References

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