6ui9

Structure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetateStructure of human ATP citrate lyase in complex with acetyl-CoA and oxaloacetate

6ui9, resolution 3.10Å Show:Asymmetric Unit Biological Assembly Structural highlights 6ui9 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Method: Electron Microscopy, Resolution 3.1Å Ligands: Experimental data: Check Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function ACLY_HUMAN ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine. See Also ATP-citrate synthase 3D structures