6tm1

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

Structural highlights

6tm1 is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 3.71Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

RAC3_HUMAN Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles.^[1]

References

↑ De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002 May;9(5):451-9. PMID:11956649

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OCA

[1] De Langhe S, Haataja L, Senadheera D, Groffen J, Heisterkamp N. Interaction of the small GTPase Rac3 with NRBP, a protein with a kinase-homology domain. Int J Mol Med. 2002 May;9(5):451-9. PMID:11956649

[1]

6tm1

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

Structural highlights

Function

See Also

References

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6tm1

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

Structural highlights

Function

See Also

References

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