3k4y

Crystal Structure of Isopentenyl Phosphate Kinase from M. jannaschii in complex with IPPCrystal Structure of Isopentenyl Phosphate Kinase from M. jannaschii in complex with IPP

Structural highlights

3k4y is a 2 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.54Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

IPK_METJA Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids. Has no activity with farnesyl phosphate.^[1] ^[2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Grochowski LL, Xu H, White RH. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. J Bacteriol. 2006 May;188(9):3192-8. PMID:16621811 doi:http://dx.doi.org/10.1128/JB.188.9.3192-3198.2006
↑ Dellas N, Noel JP. Mutation of Archaeal Isopentenyl Phosphate Kinase Highlights Mechanism and Guides Phosphorylation of Additional Isoprenoid Monophosphates. ACS Chem Biol. 2010 Apr 14. PMID:20392112 doi:10.1021/cb1000313

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OCA

[1] Grochowski LL, Xu H, White RH. Methanocaldococcus jannaschii uses a modified mevalonate pathway for biosynthesis of isopentenyl diphosphate. J Bacteriol. 2006 May;188(9):3192-8. PMID:16621811 doi:http://dx.doi.org/10.1128/JB.188.9.3192-3198.2006

[2] Dellas N, Noel JP. Mutation of Archaeal Isopentenyl Phosphate Kinase Highlights Mechanism and Guides Phosphorylation of Additional Isoprenoid Monophosphates. ACS Chem Biol. 2010 Apr 14. PMID:20392112 doi:10.1021/cb1000313

[1]

[2]

3k4y

Crystal Structure of Isopentenyl Phosphate Kinase from M. jannaschii in complex with IPPCrystal Structure of Isopentenyl Phosphate Kinase from M. jannaschii in complex with IPP

Structural highlights

Function

Evolutionary Conservation

References

Contents

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3k4y

Crystal Structure of Isopentenyl Phosphate Kinase from M. jannaschii in complex with IPPCrystal Structure of Isopentenyl Phosphate Kinase from M. jannaschii in complex with IPP

Structural highlights

Function

Evolutionary Conservation

References

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