2r7l

Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICARCrystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR

Structural highlights

2r7l is a 1 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PURP_METJA Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Ownby K, Xu H, White RH. A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis. J Biol Chem. 2005 Mar 25;280(12):10881-7. Epub 2004 Dec 28. PMID:15623504 doi:http://dx.doi.org/M413937200

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OCA

[1] Ownby K, Xu H, White RH. A Methanocaldococcus jannaschii archaeal signature gene encodes for a 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase. A new enzyme in purine biosynthesis. J Biol Chem. 2005 Mar 25;280(12):10881-7. Epub 2004 Dec 28. PMID:15623504 doi:http://dx.doi.org/M413937200

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2r7l

Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICARCrystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR

Structural highlights

Function

Evolutionary Conservation

References

Contents

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2r7l

Crystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICARCrystal structure of FAICAR synthetase (PurP) from M. jannaschii complexed with ATP and AICAR

Structural highlights

Function

Evolutionary Conservation

References

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