2mdp

The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolaseThe bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase

Structural highlights

2mdp is a 1 chain structure with sequence from Escherichia phage T7. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Solution NMR
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GP12_BPT7 Plays a role in increasing the intracellular pool of dGTP. Interacts with and inhibits host dGTPase/dgt. The complex made of the host dGTPase and gene 1.2 protein creates a GTP-binding site of high affinity. Subsequent binding of GTP to the enzyme-inhibitor complex inhibits its dissociation.^[1] ^[2]

References

↑ Nakai H, Richardson CC. The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein. J Biol Chem. 1990 Mar 15;265(8):4411-9. PMID:2155228
↑ Myers JA, Beauchamp BB, Richardson CC. Gene 1.2 protein of bacteriophage T7. Effect on deoxyribonucleotide pools. J Biol Chem. 1987 Apr 15;262(11):5288-92. PMID:3549718

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Nakai H, Richardson CC. The gene 1.2 protein of bacteriophage T7 interacts with the Escherichia coli dGTP triphosphohydrolase to form a GTP-binding protein. J Biol Chem. 1990 Mar 15;265(8):4411-9. PMID:2155228

[2] Myers JA, Beauchamp BB, Richardson CC. Gene 1.2 protein of bacteriophage T7. Effect on deoxyribonucleotide pools. J Biol Chem. 1987 Apr 15;262(11):5288-92. PMID:3549718

[1]

[2]

2mdp

The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolaseThe bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

2mdp

The bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolaseThe bacteriophage T7 encoded inhibitor (gp1.2) of E. coli dGTP triphosphohydrolase

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search