2a4v

Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidaseCrystal Structure of a truncated mutant of yeast nuclear thiol peroxidase

Structural highlights

2a4v is a 1 chain structure with sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DOT5_YEAST Has a role in telomere silencing, which is the repression of chromatin structure which leads to a stop in the transcription of nearby genes. Also has a role in the regulation of telomere length. Acts as an alkyl-hydroperoxide reductase in the nucleus during post-diauxic growth. Preferentially reduces alkyl-hydroperoxides rather than hydrogen preoxide. Acts as an antioxidant necessary for stationary phase survival.^[1] ^[2] ^[3]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C, Mahowald M, Gottschling DE. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics. 1998 Oct;150(2):613-32. PMID:9755194
↑ Cha MK, Choi YS, Hong SK, Kim WC, No KT, Kim IH. Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae. J Biol Chem. 2003 Jul 4;278(27):24636-43. Epub 2003 May 2. PMID:12730197 doi:http://dx.doi.org/10.1074/jbc.M302628200
↑ Izawa S, Kuroki N, Inoue Y. Nuclear thioredoxin peroxidase Dot5 in Saccharomyces cerevisiae: roles in oxidative stress response and disruption of telomeric silencing. Appl Microbiol Biotechnol. 2004 Mar;64(1):120-4. Epub 2003 Aug 19. PMID:12925864 doi:http://dx.doi.org/10.1007/s00253-003-1421-5

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OCA

[1] Singer MS, Kahana A, Wolf AJ, Meisinger LL, Peterson SE, Goggin C, Mahowald M, Gottschling DE. Identification of high-copy disruptors of telomeric silencing in Saccharomyces cerevisiae. Genetics. 1998 Oct;150(2):613-32. PMID:9755194

[2] Cha MK, Choi YS, Hong SK, Kim WC, No KT, Kim IH. Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae. J Biol Chem. 2003 Jul 4;278(27):24636-43. Epub 2003 May 2. PMID:12730197 doi:http://dx.doi.org/10.1074/jbc.M302628200

[3] Izawa S, Kuroki N, Inoue Y. Nuclear thioredoxin peroxidase Dot5 in Saccharomyces cerevisiae: roles in oxidative stress response and disruption of telomeric silencing. Appl Microbiol Biotechnol. 2004 Mar;64(1):120-4. Epub 2003 Aug 19. PMID:12925864 doi:http://dx.doi.org/10.1007/s00253-003-1421-5

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[2]

[3]

2a4v

Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidaseCrystal Structure of a truncated mutant of yeast nuclear thiol peroxidase

Structural highlights

Function

Evolutionary Conservation

See Also

References

Contents

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2a4v

Crystal Structure of a truncated mutant of yeast nuclear thiol peroxidaseCrystal Structure of a truncated mutant of yeast nuclear thiol peroxidase

Structural highlights

Function

Evolutionary Conservation

See Also

References

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