1ig3

From Proteopedia
Jump to navigation Jump to search

Mouse Thiamin Pyrophosphokinase Complexed with ThiaminMouse Thiamin Pyrophosphokinase Complexed with Thiamin

Structural highlights

1ig3 is a 2 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.9Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

TPK1_MOUSE Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate.[1] [2]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Nosaka K, Onozuka M, Nishino H, Nishimura H, Kawasaki Y, Ueyama H. Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA. J Biol Chem. 1999 Nov 26;274(48):34129-33. PMID:10567383
  2. ↑ Liu JY, Timm DE, Hurley TD. Pyrithiamine as a substrate for thiamine pyrophosphokinase. J Biol Chem. 2006 Mar 10;281(10):6601-7. Epub 2005 Dec 19. PMID:16365036 doi:10.1074/jbc.M510951200

1ig3, resolution 1.90Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=1ig3&oldid=4044951"