2a2v

From Proteopedia
Revision as of 10:45, 23 October 2024 by OCA (talk | contribs)
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

The solution structure of Jingzhaotoxin-XIThe solution structure of Jingzhaotoxin-XI

Structural highlights

2a2v is a 1 chain structure with sequence from Chilobrachys guangxiensis. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR, 20 models
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

JZ11A_CHIGU Inhibits voltage-gated potassium channels (Kv2.1/KCNB1 > Kv4.2/KCND2 > Kv4.1/KCND1). Also inhibits voltage-gated sodium channels of subtype Nav1.5/SCN5A (in cardiac myocytes). The toxin shifts activation towards more depolarized potentials and is suggested to bind to the extracellular S3-S4 loop of the channel. Shows no significant toxic symptoms when injected into mice and into cockroaches.[1]

References

  1. ↑ Liao Z, Yuan C, Deng M, Li J, Chen J, Yang Y, Hu W, Liang S. Solution structure and functional characterization of jingzhaotoxin-XI: a novel gating modifier of both potassium and sodium channels. Biochemistry. 2006 Dec 26;45(51):15591-600. PMID:17176080 doi:10.1021/bi061457+
Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=2a2v&oldid=4201538"