1jh5
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Crystal Structure of sTALL-1 of TNF family ligand
OverviewOverview
TALL-1/BAFF/BLyS was recently identified as a member of the tumor necrosis, factor (TNF) ligand family. The crystal structure of the functional, soluble TALL-1 (sTALL-1) has been determined at 3.0 A. sTALL-1 forms a, virus-like assembly with 200 A diameter in the crystals, containing 60, sTALL-1 monomers. The cluster formation is mediated by a "flap" region of, the sTALL-1 monomer. The virus-like assembly was also detected in solution, using gel filtration and electron microscopy. Deletion of the flap region, disrupted the formation of the virus-like assembly. The mutant sTALL-1, still bound its receptor but could not activate NF-kappaB and did not, stimulate B lymphocyte proliferation. Finally, we found the virus-like, cluster of sTALL-1 exists in physiological condition. We propose that this, virus-like assembly of sTALL-1 is the functional unit for TALL-1 in vivo.
About this StructureAbout this Structure
1JH5 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Crystal structure of sTALL-1 reveals a virus-like assembly of TNF family ligands., Liu Y, Xu L, Opalka N, Kappler J, Shu HB, Zhang G, Cell. 2002 Feb 8;108(3):383-94. PMID:11853672
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