Structural highlights
4pdc is a 6 chain structure with sequence from Cowpx and Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
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| Related: | 4ffe, 1mpu, 1hyr, 1jsk, 1kcg |
| Gene: | KLRK1, D12S2489E, NKG2D (HUMAN), CPXV018 CDS (COWPX) |
| Resources: | FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT |
Function
[NKG2D_HUMAN] Receptor for MICA, MICB, ULBP1, ULBP2, ULBP3 (ULBP2>ULBP1>ULBP3) and ULBP4. Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells. Involved in the immune surveillance exerted by T- and B-lymphocytes.
See Also