2ebo
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CORE STRUCTURE OF GP2 FROM EBOLA VIRUS
OverviewOverview
Ebola virions contain a surface transmembrane glycoprotein (GP) that is, responsible for binding to target cells and subsequent fusion of the viral, and host-cell membranes. GP is expressed as a single-chain precursor that, is posttranslationally processed into the disulfide-linked fragments GP1, and GP2. The GP2 subunit is thought to mediate membrane fusion. A soluble, fragment of the GP2 ectodomain, lacking the fusion-peptide region and the, transmembrane helix, folds into a stable, highly helical structure in, aqueous solution. Limited proteolysis studies identify a stable core of, the GP2 ectodomain. This 74-residue core, denoted Ebo-74, was, crystallized, and its x-ray structure was determined at 1.9-A resolution., Ebo-74 forms a trimer in which a long, central three-stranded coiled ... [(full description)]
About this StructureAbout this Structure
2EBO is a [Single protein] structure of sequence from [Ebola virus] with CL as [ligand]. Full crystallographic information is available from [OCA].
ReferenceReference
Core structure of the envelope glycoprotein GP2 from Ebola virus at 1.9-A resolution., Malashkevich VN, Schneider BJ, McNally ML, Milhollen MA, Pang JX, Kim PS, Proc Natl Acad Sci U S A. 1999 Mar 16;96(6):2662-7. PMID:10077567
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