Syntaxin

Function Syntaxin (Stx) are membrane-integrated proteins that are instrumental in exocytosis of vesicles. Stx-1 is essential for the formation of the SNARE complex involved in the fusion machinery in the brain. Stx-1 forms a 4-helical bundle complex with proteins SNAP-25 and VAMP2 which drives fusion of vesicles with the plasma membrane. The coiled-coil bundle structure is formed by the interactions of the complex SNARE motifs. Relevance The blockade of Stx-1 inhibits glioblastoma tumor growth and may represent a novel therapeutic tool against this fatal tumor. Structural highlights (PDB code 3hd7). The interactions of the syntaxin 1a and VAMP2 SNARE motives consist of hydrogen bond and polar interactions.

spinqualitylabelsall models Rat Syntaxin 1a SNARE motif (green) complex with VAMP2 SNARE motif (cyan) and SNAP25 SNARE motif (pink and yellow) (PDB code 3ipd) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of syntaxin3D structures of syntaxin

Updated on 02-December-2018

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• Syntaxin 1
  • 2xhe – Stx1 + Unc18 – Monosiga brevicollis
    
• Syntaxin 1A
  • 1ez3 – rStx1a N-terminal – rat
    
  • 1br0 – rStx1a N-terminal (mutant) – NMR
    
  • 1hvv – rStx1a SNARE motif
    
  • 2m8r – rStx1a SNARE motif - NMR
    
  • 1jth – rStx1a SNARE motif + SNAP25
    
  • 1urq – rStx1a SNARE motif + SNAP25 + tomosyn
    
  • 1n7s, 3hd7, 1sfc, 3ipd, 3rk2, 3rl0 – rStx1a SNARE motif + SNAP25 + VAMP2
    
  • 3rk3, 1kil – rStx1a SNARE motif + SNAP25 + complexin-1 + VAMP2
    
  • 5ccg, 5cch, 5cci – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2
    
  • 5kj7, 5kj8 – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP3
    
  • 2n1t – rStx1a SNARE motif + SNAP25 + synaptotagmin + VAMP2 - NMR
    
  • 5w5c, 5w5d – rStx1a SNARE motif + SNAP25 + VAMP2 + synaptotagmin + complexin-1
    
  • 3c98, 4jeh, 4jeu – rStx1a + Unc18
    
  • 3j96, 3j97, 3j98, 3j99, 6mdm, 6mdn – rStx17 SNARE motif + SNAP25 + rVAMP2 + vesicle fusion ATPase + SNAP–α – Cryo EM
    
• Syntaxin 6
  • 1lvf – rStx6 N-terminal
    
  • 4j2c – hStx6 + vacuolar protein sorting-associated protein peptide – human
    
• Syntaxin 7
  • 1gl2 – mStx7 core fragment + VAMP8 + rStx8 core fragment + VTI1-RP2 - mouse
    
• Syntaxin 10
  • 4dnd – hStx10
    
• Syntaxin 12
  • 2dnx – hStx12 N-terminal - NMR
    
• Syntaxin 13
  • 2nps – rStx13 SNARE motif + VAMP4 + hStx6 SNARE motif + VTI1-RP2
    
• Syntaxin 17
  • 4wy4 – rStx17 SNARE motif + SNAP29 + VAMP8
    
• s-syntaxin
  • 1s94 – LpStx Habc domain – Loligo pealei
    
  • 1l4a – LpStx1a SNARE motif + SNAP25 + synaptobrevin + synaphin A
    
• Syntaxin VAM3
  • 1hs7 – Stx N-terminal – yeast - NMR