User:Gabriel Pons/Sandbox 3

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TGFβ signalling pathwayTGFβ signalling pathway

TGFβ belongs to a group of extracellular signals involved in the regulation of several cellular processes as cell proliferation, differentiation, Apoptosis, development, cellular adhesion, immune surveillance and Tissue homeostasis. In addition they are involved in pathological conditions as autoimmune diseases, Inflammatory diseases, cancer and Cardiovascular diseases

LigandsLigands

TGFβ represents a paradigm of these group of ligands

TGFβ isoformsTGFβ isoforms

TGFβ receptorsTGFβ receptors

TGFβ receptor ectodomainTGFβ receptor ectodomain

TGFβ receptor endodomainTGFβ receptor endodomain

TGFβ signallingTGFβ signalling

Latent TGFβ structure and activationLatent TGFβ structure and activation

pro-TGFβ-1 processing pro-TGFβ-1 processing

TGFβ-1:TβRII:TβRI ternary complex TGFβ-1:TβRII:TβRI ternary complex

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