4ai0

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Flo5A showing a heptanuclear gadolinium cluster on its surface after 9 min of soakingFlo5A showing a heptanuclear gadolinium cluster on its surface after 9 min of soaking

Structural highlights

4ai0 is a 1 chain structure with sequence from Saccharomyces cerevisiae s288c. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Resources:FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

Protein-bound contrast: The unusual observation of a heptanuclear gadolinium-oxo cluster on the surface of the cell-adhesion protein Flo5A establishes the basis for directed incorporation of poly-lanthanide clusters into biomolecules. The observed gadolinium cluster might serve as a paradigm for the design of protein-based MRI contrast agents.

Complex Gadolinium-Oxo Clusters Formed along Concave Protein Surfaces.,Veelders M, Essen LO Chembiochem. 2012 Aug 31. doi: 10.1002/cbic.201200441. PMID:22936626[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Veelders M, Essen LO. Complex Gadolinium-Oxo Clusters Formed along Concave Protein Surfaces. Chembiochem. 2012 Aug 31. doi: 10.1002/cbic.201200441. PMID:22936626 doi:http://dx.doi.org/10.1002/cbic.201200441

4ai0, resolution 1.80Å

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