Interferon regulatory factor (IRF) regulate transcription of interferons.
- IRF-1 functions as a transcriptional activator by binding to an interferon-stimulated response element in the gene promoter.
- IRF-3 and IRF-7 are activated by viruses or after binding to Toll-like receptors.
- IRF-4 is lymphoid-specific and functions in the development of immune cells.
3D structures of interferon regulatory factor
Updated on 05-May-2025
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- Interferon regulatory factor 1
- 1if1 - mIRF DNA binding domain + DNA – mouse
- Interferon regulatory factor 2
- 1irf, 1irg – mIRF DNA binding domain – NMR
- 2irf - mIRF DNA binding domain + DNA
- Interferon regulatory factor 3
- 1qwt, 1j2f – mIRF
- 3a77 – hIRF DNA binding domain
- 3qu6 - hIRF DNA binding domain (mutant)
- 1t2k - hIRF DNA binding domain + interferon B enhancer + transcription factor AP-1 + DNA – human
- 2o6g - hIRF DNA binding domain + interferon B enhancer
- 2pi0 - hIRF DNA binding domain + interferon B promoter
- 1zoq – hIRF + CREB-binding protein
- 2o61 – hIRF3/IRF7/transcription factor + nuclear factor + DNA
- Interferon regulatory factor 4
- 2dll – hIRF IRF domain - NMR
- Interferon regulatory factor 5
- 3dsh – hIRF IRF domain (mutant)
- Interferon regulatory factor 7
- 3qu3 - mIRF DNA binding domain
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