3op5
Structural highlights
Disease[VRK1_HUMAN] Pontocerebellar hypoplasia type 1. The disease is caused by mutations affecting the gene represented in this entry. Function[VRK1_HUMAN] Serine/threonine kinase involved in Golgi disassembly during the cell cycle: following phosphorylation by PLK3 during mitosis, required to induce Golgi fragmentation. Acts by mediating phosphorylation of downstream target protein. Phosphorylates 'Thr-18' of p53/TP53 and may thereby prevent the interaction between p53/TP53 and MDM2. Phosphorylates casein and histone H3. Phosphorylates BANF1: disrupts its ability to bind DNA, reduces its binding to LEM domain-containing proteins and causes its relocalization from the nucleus to the cytoplasm. Phosphorylates ATF2 which activates its transcriptional activity.[1] [2] [3] [4] [5] [6] Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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OCA- Homo sapiens
- Non-specific serine/threonine protein kinase
- Allerston, C K.
- Arrowsmith, C H.
- Berridge, G.
- Bountra, C.
- Brenner, B.
- Chalk, R.
- Das, S.
- Delft, F von.
- Edwards, A M.
- Elkins, J M.
- Eswaran, J.
- Fedorov, O.
- Filippakopoulos, P.
- Gileadi, O.
- Keates, T.
- King, O.
- Knapp, S.
- Krojer, T.
- Rellos, P.
- SGC, Structural Genomics Consortium.
- Savitsky, P.
- Uttarkar, S.
- Weigelt, J.
- Adenosine triphosphate
- Amino acid sequence
- Binding site
- Catalytic domain
- Model
- Molecular
- Molecular sequence data
- Phosphotransferase
- Protein conformation
- Protein folding
- Sgc
- Structural genomic
- Structural genomics consortium
- Surface entropy reduction
- Transferase