Cruzain

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Cruzain (Cru) is the major cysteine protease present in Trypanosoma cruzi which is the parasite causing Chagas disease.

3D structures of cruzain

Updated on 28-May-2025

1aim, 2aim, 1me3, 1me4 – Cru catalytic domain + methylketone inhibitor – Trypanosoma cruzi

1f29, 1f2a, 1f2b, 1f2c, 1ewo, 3lxs - Cru catalytic domain + vinyl sulfone derived inhibitor
1ewl, 1ewm – Cru catalytic domain + methylbutane inhibitor


Structure of cruzain complex with methylketone inhibitor (PDB entry 1me3)

Drag the structure with the mouse to rotate

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Michal Harel, Alexander Berchansky