2j1x
HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268DHUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D
Template:ABSTRACT PUBMED 17015838
About this StructureAbout this Structure
2j1x is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
See AlsoSee Also
ReferenceReference
- ↑ Joerger AC, Ang HC, Fersht AR. Structural basis for understanding oncogenic p53 mutations and designing rescue drugs. Proc Natl Acad Sci U S A. 2006 Oct 10;103(41):15056-61. Epub 2006 Oct 2. PMID:17015838
- ↑ Joerger AC, Allen MD, Fersht AR. Crystal structure of a superstable mutant of human p53 core domain. Insights into the mechanism of rescuing oncogenic mutations. J Biol Chem. 2004 Jan 9;279(2):1291-6. Epub 2003 Oct 8. PMID:14534297 doi:10.1074/jbc.M309732200
- ↑ Joerger AC, Ang HC, Veprintsev DB, Blair CM, Fersht AR. Structures of p53 cancer mutants and mechanism of rescue by second-site suppressor mutations. J Biol Chem. 2005 Apr 22;280(16):16030-7. Epub 2005 Feb 9. PMID:15703170 doi:http://dx.doi.org/10.1074/jbc.M500179200
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OCACategories:
- Pages with broken file links
- Homo sapiens
- Fersht, A R.
- Joerger, A C.
- Activator
- Anti-oncogene
- Apoptosis
- Cell cycle
- Disease mutation
- Dna-binding
- Dna-binding protein
- Glycoprotein
- Host-virus interaction
- Li- fraumeni syndrome
- Li-fraumeni syndrome
- Metal-binding
- Nuclear protein
- P53 dna-binding domain
- Phosphorylation
- Second-site suppressor mutation
- Superstable mutant
- Transcription
- Transcription regulation
- Transferase
- Tumor suppressor