3ig6
Low molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complexLow molecular weigth human Urokinase type Plasminogen activator 2-[6-(3'-Aminomethyl-biphenyl-3-yloxy)-4-(3-dimethylamino-pyrrolidin-1-yl)-3,5-difluoro-pyridin-2-yloxy]-4-dimethylamino-benzoic acid complex
Template:ABSTRACT PUBMED 19703768
DiseaseDisease
Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]
About this StructureAbout this Structure
3IG6 is a 4 chains structure with sequences from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ West CW, Adler M, Arnaiz D, Chen D, Chu K, Gualtieri G, Ho E, Huwe C, Light D, Phillips G, Pulk R, Sukovich D, Whitlow M, Yuan S, Bryant J. Identification of orally bioavailable, non-amidine inhibitors of Urokinase Plasminogen Activator (uPA). Bioorg Med Chem Lett. 2009 Oct 1;19(19):5712-5. Epub 2009 Aug 7. PMID:19703768 doi:10.1016/j.bmcl.2009.08.008
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OCACategories:
- Pages with broken file links
- Homo sapiens
- U-plasminogen activator
- Adler, M.
- Whitlow, M.
- Blood coagulation
- Disulfide bond
- Egf-like domain
- Fibrinolysis
- Glycoprotein
- Hydrolase
- Kringle
- Pharmaceutical
- Phosphoprotein
- Plasminogen activation
- Polymorphism
- Protease
- S1 site inhibitor
- Secreted
- Selective
- Serine protease
- Structure-based drug design
- Urokinase
- Zymogen