Jonathan O'Donnell sandbox 1
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| 3d06, resolution 1.20Å () | |||||||||
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| Ligands: | |||||||||
| Gene: | TP53 (Homo sapiens) | ||||||||
| Related: | 3d05, 3d07, 3d08, 3d09, 3d0a | ||||||||
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| Resources: | FirstGlance, OCA, RCSB, PDBsum | ||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||
Human p53 core domain with hot spot mutation R249S (I)Human p53 core domain with hot spot mutation R249S (I)
Template:ABSTRACT PUBMED 18996393
DiseaseDisease
Known disease associated with this structure: Adrenal cortical carcinoma OMIM:[191170], Breast cancer OMIM:[191170], Colorectal cancer OMIM:[191170], Hepatocellular carcinoma OMIM:[191170], Histiocytoma OMIM:[191170], Li-Fraumeni syndrome OMIM:[191170], Multiple malignancy syndrome OMIM:[191170], Nasopharyngeal carcinoma OMIM:[191170], Osteosarcoma OMIM:[191170], Pancreatic cancer OMIM:[191170], Thyroid carcinoma OMIM:[191170]
About this StructureAbout this Structure
3D06 is a 1 chain structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Suad O, Rozenberg H, Brosh R, Diskin-Posner Y, Kessler N, Shimon LJ, Frolow F, Liran A, Rotter V, Shakked Z. Structural basis of restoring sequence-specific DNA binding and transactivation to mutant p53 by suppressor mutations. J Mol Biol. 2009 Jan 9;385(1):249-65. Epub 2008 Oct 30. PMID:18996393 doi:10.1016/j.jmb.2008.10.063
Page seeded by OCA on Wed Jan 21 10:44:12 2009
Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
Ann TaylorCategories:
- Homo sapiens
- Frolow, F.
- Rozenberg, H.
- Shakked, Z.
- Shimon, L J.W.
- Suad, O.
- Acetylation
- Activator
- Alternative splicing
- Anti-oncogene
- Apoptosis
- Cell cycle
- Covalent protein-rna linkage
- Cytoplasm
- Disease mutation
- Dna-binding
- Endoplasmic reticulum
- Glycoprotein
- Host-virus interaction
- Li-fraumeni syndrome
- Loop-sheet-helix motif
- Metal-binding
- Methylation
- Mutant protein
- Nucleus
- P53
- Phosphoprotein
- Polymorphism
- Transcription
- Transcription regulation
- Ubl conjugation
- Zinc