1u9b
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MURINE/HUMAN UBIQUITIN-CONJUGATING ENZYME UBC9
OverviewOverview
Murine/human ubiquitin-conjugating enzyme Ubc9 is a functional homolog of, Saccharomyces cerevisiae Ubc9 that is essential for the viability of yeast, cells with a specific role in the G2-M transition of the cell cycle. The, structure of recombinant mammalian Ubc9 has been determined from two, crystal forms at 2.0 A resolution. Like Arabidopsis thaliana Ubc1 and S., cerevisiae Ubc4, murine/human Ubc9 was crystallized as a monomer, suggesting that previously reported hetero- and homo-interactions among, Ubcs may be relatively weak or indirect. Compared with the known crystal, structures of Ubc1 and Ubc4, which regulate different cellular processes, Ubc9 has a 5-residue insertion that forms a very exposed tight, beta-hairpin and a 2-residue insertion that forms a bulge in a loop close, to ... [(full description)]
About this StructureAbout this Structure
1U9B is a [Single protein] structure of sequence from [Mus musculus]. Active as [[1]], with EC number [6.3.2.19]. Full crystallographic information is available from [OCA].
ReferenceReference
Crystal structure of murine/human Ubc9 provides insight into the variability of the ubiquitin-conjugating system., Tong H, Hateboer G, Perrakis A, Bernards R, Sixma TK, J Biol Chem. 1997 Aug 22;272(34):21381-7. PMID:9261152
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