3cd8
X-ray Structure of c-Met with triazolopyridazine Inhibitor.X-ray Structure of c-Met with triazolopyridazine Inhibitor.
Template:ABSTRACT PUBMED 18426196
DiseaseDisease
Known disease associated with this structure: Hepatocellular carcinoma, childhood type OMIM:[164860], Renal cell carcinoma, papillary, familial and sporadic OMIM:[164860], Autism, suseptibility to, 9 OMIM:[164860]
About this StructureAbout this Structure
3CD8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase., Albrecht BK, Harmange JC, Bauer D, Berry L, Bode C, Boezio AA, Chen A, Choquette D, Dussault I, Fridrich C, Hirai S, Hoffman D, Larrow JF, Kaplan-Lefko P, Lin J, Lohman J, Long AM, Moriguchi J, O'Connor A, Potashman MH, Reese M, Rex K, Siegmund A, Shah K, Shimanovich R, Springer SK, Teffera Y, Yang Y, Zhang Y, Bellon SF, J Med Chem. 2008 May 22;51(10):2879-82. Epub 2008 Apr 22. PMID:18426196
Page seeded by OCA on Mon Jul 28 01:12:00 2008
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- Homo sapiens
- Receptor protein-tyrosine kinase
- Single protein
- Albrecht, B K.
- Bauer, D.
- Bellon, S F.
- Choquette, D.
- Dussault, I.
- Harmange, J C.
- Atp-binding
- C-met
- Glycoprotein
- Kinase
- Membrane
- Nucleotide-binding
- Phosphoprotein
- Proto-oncogene
- Receptor
- Transferase
- Transmembrane
- Triazolopyridazine
- Tyrosine-protein kinase