Enzyme I of the Phosphoenolpyruvate:Sugar Phosphotransferase System

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A Molecular machineA Molecular machine

(this is a very preliminar page for Dr Osnat Herzberg)

<swf width="300" height="300">https://carb.umbi.umd.edu/system/files/ei_release.swf</swf>

You may also download the full High Resolution video.

Enzyme I of the bacterial PEP:sugar phosphotransferase system (PTS), transfers the phosphoryl group of PEP to the next PTS protein, HPr. HPr~P then proceeds to phosphorylate a sugar specific permease responsible for the uptake of the incoming sugar. Again, PEP and HPR bind remotely from one another.

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Jaime Prilusky, Osnat Herzberg, Eran Hodis, David Canner, Michal Harel, Karl Oberholser, Eric Martz