2qr7
2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative
OverviewOverview
The X-ray structure at 2.0-A resolution of the p90 ribosomal S6 kinase 2 C-terminal kinase domain revealed a C-terminal autoinhibitory alphaL-helix that was embedded in the kinase scaffold and determines the inactive kinase conformation. We suggest a mechanism of activation through displacement of the alphaL-helix and rearrangement of the conserved residue Glu500, as well as the reorganization of the T-loop into the active conformation.
About this StructureAbout this Structure
2QR7 is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
ReferenceReference
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2., Malakhova M, Tereshko V, Lee SY, Yao K, Cho YY, Bode A, Dong Z, Nat Struct Mol Biol. 2008 Jan;15(1):112-3. Epub 2007 Dec 16. PMID:18084304 Page seeded by OCA on Sun May 4 15:28:21 2008