2adu
Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor
OverviewOverview
Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are of interest as potential treatments for cancer. A new class of small molecule reversible inhibitors of hMetAP2 was discovered and optimized, the 4-aryl-1,2,3-triazoles. Compound 24, a potent inhibitor of cobalt-activated hMetAP2, also inhibits human and mouse endothelial cell growth. Using a mouse matrigel model, this reversible hMetAP2 inhibitor was also shown to inhibit angiogenesis in vivo.
About this StructureAbout this Structure
2ADU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo., Kallander LS, Lu Q, Chen W, Tomaszek T, Yang G, Tew D, Meek TD, Hofmann GA, Schulz-Pritchard CK, Smith WW, Janson CA, Ryan MD, Zhang GF, Johanson KO, Kirkpatrick RB, Ho TF, Fisher PW, Mattern MR, Johnson RK, Hansbury MJ, Winkler JD, Ward KW, Veber DF, Thompson SK, J Med Chem. 2005 Sep 8;48(18):5644-7. PMID:16134930 Page seeded by OCA on Sat May 3 18:55:15 2008
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- Homo sapiens
- Methionyl aminopeptidase
- Single protein
- Chen, W.
- Fisher, P W.
- Hansbury, M J.
- Ho, T F.
- Hofmann, G A.
- Janson, C A.
- Johanson, K O.
- Johnson, R K.
- Kallander, L S.
- Kirkpatrick, R B.
- Lu, Q.
- Mattern, M R.
- Meek, T D.
- Ryan, M D.
- Schulz-Pritchard, C K.
- Smith, W W.
- Tew, D.
- Thompson, S K.
- Tomaszek, T.
- Veber, D F.
- Ward, K W.
- Winkler, J D.
- Yang, G.
- Zhang, G F.
- Aminopeptidase
- Hydrolase
- Metal binding
- Protease