7yo3

From Proteopedia
Revision as of 12:05, 30 August 2023 by OCA (talk | contribs)
Jump to navigation Jump to search

Cryo-EM structure of human Slo1-LRRC26 complex with C4 symmetryCryo-EM structure of human Slo1-LRRC26 complex with C4 symmetry

Structural highlights

7yo3 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 3.1Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

LRC26_HUMAN Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low-voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium.[1] [2]

References

  1. ↑ Yan J, Aldrich RW. LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature. 2010 Jul 22;466(7305):513-6. PMID:20613726 doi:10.1038/nature09162
  2. ↑ Yan J, Aldrich RW. BK potassium channel modulation by leucine-rich repeat-containing proteins. Proc Natl Acad Sci U S A. 2012 May 15;109(20):7917-22. PMID:22547800 doi:10.1073/pnas.1205435109

7yo3, resolution 3.10Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
Retrieved from "https://proteopedia.openfox.io/wiki/index.php?title=7yo3&oldid=3848756"