7ezt

The structure and functional mechanism of nucleotide regulated acetylhexosaminidase Am2136 from Akkermansia muciniphilaThe structure and functional mechanism of nucleotide regulated acetylhexosaminidase Am2136 from Akkermansia muciniphila

Structural highlights

7ezt is a 4 chain structure with sequence from Akkermansia muciniphila ATCC BAA-835. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.81Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

H2136_AKKM8 Potentially capable of cleaving the specific glycoside linkages in the process of mucin degradation in human intestinal tract (Probable). Hydrolyzes synthetic substrate pNP-beta-GlcNAc with high activity and pNP-beta-GalNAc to a lot lesser extent. Does not hydrolyze pNP-alpha-GalNAc.^[1]

References

↑ Chen X, Li M, Wang Y, Tang R, Zhang M. Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a beta-N-acetylhexosaminidase in Akkermansia muciniphila. Biochem Biophys Res Commun. 2019 Sep 10;517(1):29-35. doi:, 10.1016/j.bbrc.2019.06.150. Epub 2019 Jul 23. PMID:31345574 doi:http://dx.doi.org/10.1016/j.bbrc.2019.06.150

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OCA

[1] Chen X, Li M, Wang Y, Tang R, Zhang M. Biochemical characteristics and crystallographic evidence for substrate-assisted catalysis of a beta-N-acetylhexosaminidase in Akkermansia muciniphila. Biochem Biophys Res Commun. 2019 Sep 10;517(1):29-35. doi:, 10.1016/j.bbrc.2019.06.150. Epub 2019 Jul 23. PMID:31345574 doi:http://dx.doi.org/10.1016/j.bbrc.2019.06.150

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