Rab5 GDP/GTP exchange factor

Function

Rab5 GDP/GTP exchange factor (Rabex5) is a guanine nucleotide exchange factor. Rabex5 stimulates nucleotide exchange on Rab5. Rabex can act as a ubiqiutin ligase. It forms a tight complex with rabaptin which augments its exchange activity. The rabex5-rabaptin complex is critical to endosomal fusion^[1].

Structural highlights

The forming a 3-helix bundle^[2].

Human rabex-5 (cyan) complex with rabaptin (green and deeppink) and phosphate ion (PDB code 4n3z).

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3D Structures of Rab5 GDP/GTP exchange factor3D Structures of Rab5 GDP/GTP exchange factor

Updated on 15-October-2020

1txu – hRabex5 Vps9 domain – human
4n3x – hRabex5 CC domain
2fid, 2fif – bRabex5 zinc finger and ubiquitin interacting motif + ubiquitin – bovine
2c7m, 2c7n – hRabex5 ubiquitin interacting motif + ubiquitin
2ot3 – hRabex5 Vps9 domain + Ras-related protein Rab21
4n3z – hRabex5 5δ + Rabaptin
4q9u – hRabex5 5δ (mutant) + Ras-related protein Rab5A
4n3y – hRabex5 5CC domain + Rab GTPase-binding effector protein

ReferencesReferences

↑ Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142
↑ Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

[1] Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142

[2] Horiuchi H, Lippe R, McBride HM, Rubino M, Woodman P, Stenmark H, Rybin V, Wilm M, Ashman K, Mann M, Zerial M. A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. Cell. 1997 Sep 19;90(6):1149-59. PMID:9323142

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