Collagenase (non-MMP)

Collagenase (Col) catalyzes the breaking of peptide bonds in collagen. Col cleaves pro-collagen to create collagen. Some collagenases are part of the Matrix metalloproteinase family. Relevance Col is used for therapy of wounds, Dupuytren's contracture and Peyronie's disease. Structural highlights Clostridium histolycum collagenase contains several domains among them: peptidase domain (residues 331-721), polycystic kidney disease domain (PKD residues 792-880), collagen-binding domain (CBD residues 1003-1118). The peptidase domain contains a , a and an . Water molecules are shown as red spheres. . 3D Structures of collagenase Collagenase 3D structures

spinqualitylabelsall models Collagenase H peptidase domain (cyan) complex with peptidic inhibitor, isopentenyl phosphate, Ca+2 (green) and Zn+2 (grey) ions (PDB entry 4arf) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image