CXC chemokine receptor

CXC chemokine receptors bind to cytokines of the CXC chemokine family. CXCR4 is specific for Stromal Derived Factor 1 (SDF-1α, known also as CXCL12).

CXCR1 recognizes CXC chemokines with ELR amino acids adjacent to the C-terminal CXC motif.^[1]
CXCR2 is a critical mediator of neutrophil-mediated host defense in Pseudomonas pneumonia.^[2]
CXCR4 is used by HIV to infect CD4+ T cells. The biological unit probably is a ^[3].

(PDB code 3oe0).

.

Human CXCR4/lysozyme chimera complex with antagonist citrulline (PDB code 3oe0)

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3D Structures of CXC chemokine receptor3D Structures of CXC chemokine receptor

Updated on 09-June-2024

ReferencesReferences

↑ Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature. 2012 Nov 29;491(7426):779-83. doi: 10.1038/nature11580. Epub 2012 Oct 21. PMID:23086146 doi:http://dx.doi.org/10.1038/nature11580
↑ Tsai WC, Strieter RM, Mehrad B, Newstead MW, Zeng X, Standiford TJ. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun. 2000 Jul;68(7):4289-96. doi: 10.1128/IAI.68.7.4289-4296.2000. PMID:10858247 doi:http://dx.doi.org/10.1128/IAI.68.7.4289-4296.2000
↑ Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396

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Alexander Berchansky, Michal Harel, Jaime Prilusky, Joel L. Sussman

[1] Park SH, Das BB, Casagrande F, Tian Y, Nothnagel HJ, Chu M, Kiefer H, Maier K, De Angelis AA, Marassi FM, Opella SJ. Structure of the chemokine receptor CXCR1 in phospholipid bilayers. Nature. 2012 Nov 29;491(7426):779-83. doi: 10.1038/nature11580. Epub 2012 Oct 21. PMID:23086146 doi:http://dx.doi.org/10.1038/nature11580

[2] Tsai WC, Strieter RM, Mehrad B, Newstead MW, Zeng X, Standiford TJ. CXC chemokine receptor CXCR2 is essential for protective innate host response in murine Pseudomonas aeruginosa pneumonia. Infect Immun. 2000 Jul;68(7):4289-96. doi: 10.1128/IAI.68.7.4289-4296.2000. PMID:10858247 doi:http://dx.doi.org/10.1128/IAI.68.7.4289-4296.2000

[3] Wu B, Chien EY, Mol CD, Fenalti G, Liu W, Katritch V, Abagyan R, Brooun A, Wells P, Bi FC, Hamel DJ, Kuhn P, Handel TM, Cherezov V, Stevens RC. Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists. Science. 2010 Oct 7. PMID:20929726 doi:10.1126/science.1194396

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CXC chemokine receptor

3D Structures of CXC chemokine receptor3D Structures of CXC chemokine receptor

ReferencesReferences

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