Crystal Structure of the Methanococcus jannaschii Mevalonate KinaseCrystal Structure of the Methanococcus jannaschii Mevalonate Kinase
Structural highlights
1kkh is a 1 chain structure with sequence from Methanocaldococcus jannaschii. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
MVK_METJA Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.[HAMAP-Rule:MF_00217][1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Huang KX, Scott AI, Bennett GN. Overexpression, purification, and characterization of the thermostable mevalonate kinase from Methanococcus jannaschii. Protein Expr Purif. 1999 Oct;17(1):33-40. PMID:10497066 doi:10.1006/prep.1999.1106
↑Chu X, Liu X, Yau M, Leung YC, Li D. Expression and purification of Arg196 and Lys272 mutants of mevalonate kinase from Methanococcus jannaschii. Protein Expr Purif. 2003 Aug;30(2):210-8. PMID:12880770 doi:10.1016/s1046-5928(03)00101-3
