THE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUMTHE 1.8 A STRUCTURE OF COLLAGENASE FROM HYPODERMA LINEATUM
Structural highlights
1hyl is a 2 chain structure with sequence from Hypoderma lineatum. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
COGS_HYPLI This enzyme is a serine protease capable of degrading the native triple helix of collagen. Also cleaves the B chain of insulin at the 15-Leu-|-Try-16 and 22-Arg-|-Gly-23 bonds. Hydrolyzes casein, but not Px-Pro-Leu-Gly-Pro-DArg, BzArgNHPh, AcTyrNHPh, 2-naphthyl phosphate, 2-naphthyl butyrate, 2-naphthyl caprylate, 2-naphthyl myristate, L-leucine 2-2-naphthylamide, L-valine 2-naphthylamide, L-cysteine 2-naphthylamide or L-glutarylphenylalanine 2-naphthylamide.[1][2]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
↑Lecroisey A, Boulard C, Keil B. Chemical and enzymatic characterization of the collagenase from the insect Hypoderma lineatum. Eur J Biochem. 1979 Nov;101(2):385-93. PMID:230030
↑Lecroisey A, Keil B. Specificity of the collagenase from the insect Hypoderma lineatum. Eur J Biochem. 1985 Oct 1;152(1):123-30. PMID:2995028
