1r4q is a 12 chain structure with sequence from Shigella dysenteriae. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
STXA_SHIDY The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
