8c8s

Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).

Structural highlights

8c8s is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.8Å
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DCR1A_HUMAN May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons.^[1]

References

↑ Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol. 2004 Dec;24(23):10448-55. PMID:15542852 doi:http://dx.doi.org/24/23/10448

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Akhter S, Richie CT, Deng JM, Brey E, Zhang X, Patrick C Jr, Behringer RR, Legerski RJ. Deficiency in SNM1 abolishes an early mitotic checkpoint induced by spindle stress. Mol Cell Biol. 2004 Dec;24(23):10448-55. PMID:15542852 doi:http://dx.doi.org/24/23/10448

[1]

8c8s

Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).

Structural highlights

Function

References

Contents

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

8c8s

Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).Crystal structure of human DNA cross-link repair 1A in complex with hydroxamic acid inhibitor (compound 21).

Structural highlights

Function

References

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Navigation menu

Search