8b10

Crystal Structure of Shank2-SAM mutant domain - L1800WCrystal Structure of Shank2-SAM mutant domain - L1800W

Structural highlights

8b10 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 1.95Å
Ligands:	, ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SHAN2_HUMAN NON RARE IN EUROPE: Autism. Disease susceptibility is associated with variants affecting the gene represented in this entry.

Function

SHAN2_HUMAN Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

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OCA