2v8o

Structure of the Murray Valley encephalitis virus RNA helicase to 1. 9A resolutionStructure of the Murray Valley encephalitis virus RNA helicase to 1. 9A resolution

Structural highlights 2v8o is a 1 chain structure with sequence from Murray valley encephalitis virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Activity: Flavivirin, with EC number 3.4.21.91 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Murray Valley encephalitis virus (MVEV), a mosquito-borne flavivirus endemic to Australia, is closely related to Japanese encephalitis virus and West Nile virus. Nonstructural protein 3 (NS3) is a multifunctional enzyme with serine protease and DEXH/D-box helicase domains, whose activity is central to flavivirus replication and is therefore a possible target for anti-flaviviral compounds. Cloning, purification, and crystal structure determination to 1.9 Angstrom resolution of the NS3 helicase of MVEV and characterization of its enzymatic activity is reported. Comparison with the structures of helicases from related viruses supports a possible mechanism of ATP hydrolysis-driven strand separation. Structure of the Murray Valley encephalitis virus RNA helicase at 1.9 Angstrom resolution.,Mancini EJ, Assenberg R, Verma A, Walter TS, Tuma R, Grimes JM, Owens RJ, Stuart DI Protein Sci. 2007 Oct;16(10):2294-300. PMID:17893366 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Helicase 3D structures

spinqualitylabelsall models 2v8o, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image