7csm

Crystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variantCrystal structure of Sulfurisphaera tokodaii O6-methylguanine methyltransferase C120S variant

Structural highlights 7csm is a 1 chain structure with sequence from Sulto. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: Gene: ogt, STK_09670 (SULTO) Activity: [protein-cysteine_S-methyltransferase Methylated-DNA--[protein]-cysteine S-methyltransferase], with EC number 2.1.1.63 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Function [OGT_SULTO] Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated (By similarity).

spinqualitylabelsall models 7csm, resolution 1.25Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image