5n2l

Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogueCrystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue

Structural highlights

5n2l is a 4 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Gene:	BRD2, KIAA9001, RING3 (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[BRD2_HUMAN] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.^[1]

References

↑ LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

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OCA

[1] LeRoy G, Rickards B, Flint SJ. The double bromodomain proteins Brd2 and Brd3 couple histone acetylation to transcription. Mol Cell. 2008 Apr 11;30(1):51-60. doi: 10.1016/j.molcel.2008.01.018. PMID:18406326 doi:10.1016/j.molcel.2008.01.018

[1]

5n2l

Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogueCrystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue

Structural highlights

Function

See Also

References

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5n2l

Crystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogueCrystal structure of the second bromodomain of human BRD2 in complex with a tetrahydroquinoline analogue

Structural highlights

Function

See Also

References

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