8gih

Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24Structure of Hepatitis B Virus Capsid Y132A mutant in complex with Compound 24

Structural highlights

8gih is a 6 chain structure with sequence from Hepatitis B virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

L7R9I1_HBV

Publication Abstract from PubMed

The HBV capsid core protein serves a number of important functions in the viral life cycle enabling chronic HBV infection to persist, and therefore is a promising drug target. Interfering with capsid assembly has shown efficacy in clinical trials with small molecule capsid assembly modulators (CAMs). Herein is described the further optimization of a progressive series of diazepinone HBV CAMs.

Diazepinone HBV capsid assembly modulators.,Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD Bioorg Med Chem Lett. 2022 Sep 15;72:128823. doi: 10.1016/j.bmcl.2022.128823. , Epub 2022 May 27. PMID:35644301^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD. Diazepinone HBV capsid assembly modulators. Bioorg Med Chem Lett. 2022 Sep 15;72:128823. PMID:35644301 doi:10.1016/j.bmcl.2022.128823

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OCA

[1] Kuduk SD, DeRatt LG, Stoops B, Shaffer P, Lam AM, Espiritu C, Vogel R, Lau V, Flores OA, Hartman GD. Diazepinone HBV capsid assembly modulators. Bioorg Med Chem Lett. 2022 Sep 15;72:128823. PMID:35644301 doi:10.1016/j.bmcl.2022.128823

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