3l5k

The crystal structure of human Haloacid Dehalogenase-like Hydrolase Domain containing 1A (HDHD1A)The crystal structure of human Haloacid Dehalogenase-like Hydrolase Domain containing 1A (HDHD1A)

Structural highlights

3l5k is a 1 chain structure with sequence from Human. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	2pib, 3hlt, 3k1z, 2w4m
Gene:	HDHD1A (HUMAN)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[HDHD1_HUMAN] Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine.^[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

↑ Preumont A, Rzem R, Vertommen D, Van Schaftingen E. HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase. Biochem J. 2010 Oct 15;431(2):237-44. doi: 10.1042/BJ20100174. PMID:20722631 doi:http://dx.doi.org/10.1042/BJ20100174

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OCA

[1] Preumont A, Rzem R, Vertommen D, Van Schaftingen E. HDHD1, which is often deleted in X-linked ichthyosis, encodes a pseudouridine-5'-phosphatase. Biochem J. 2010 Oct 15;431(2):237-44. doi: 10.1042/BJ20100174. PMID:20722631 doi:http://dx.doi.org/10.1042/BJ20100174

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