5bpv

Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278ACrystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A

Structural highlights

5bpv is a 2 chain structure with sequence from Zebov. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Gene:	VP35 (ZEBOV)
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[VP35_EBOZ5] Acts as a polymerase cofactor in the RNA polymerase transcription and replication complex. Prevents establishment of cellular antiviral state by blocking virus-induced phosphorylation and activation of interferon regulatory factor 3 (IRF3), a transcription factor critical for the induction of interferons alpha and beta. This blockage is produced through the interaction with and inhibition host IKBKE and TBK1 producing a strong inhibition of the phosphorylation and activation of IRF3. Also inhibits the antiviral effect mediated by the interferon-induced, double-stranded RNA-activated protein kinase EIF2AK2/PKR (By similarity).

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OCA