4wbg

Crystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenamCrystal structure of class C beta-lactamase Mox-1 covalently complexed with aztorenam

Structural highlights 4wbg is a 1 chain structure with sequence from "bacillus_pneumoniae"_(schroeter_1886)_flugge_1886 "bacillus pneumoniae" (schroeter 1886) flugge 1886. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: , , Related: 3w8k Gene: blaMOX-1 ("Bacillus pneumoniae" (Schroeter 1886) Flugge 1886) Activity: Beta-lactamase, with EC number 3.5.2.6 Resources: FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT Publication Abstract from PubMed We solved the crystal structure of a class C beta-lactamase MOX-1 complexed with an inhibitor, aztreonam, at 1.9A resolution. The main-chain oxygen of Ser315 interacts with the amide nitrogen of aztreonam. Surprisingly, compared to the free MOX-1 structure, this main-chain carboxyl changes its position significantly upon binding aztreonam. This result indicates that the interaction between MOX-1 and beta-lactams can be accompanied by conformational changes of the B3 beta-strand main chain. A Conformational Change Observed in the Active Site of Class C beta-Lactamase MOX-1 in Binding Aztreonam.,Oguri T, Ishii Y, Shimizu-Ibuka A Antimicrob Agents Chemother. 2015 Jun 8. pii: AAC.04428-14. PMID:26055361 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Beta-lactamase 3D structures

spinqualitylabelsall models 4wbg, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image