Acetylcholinesterase 3D structures

3D Structures of Acetylcholinesterase3D Structures of Acetylcholinesterase

Updated on 16-February-2023

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• Acetylcholinesterase - AChE native
  • 7e3d – hAChE - human
    
  • 6o69 – hAChE (mutant)
    
  • 3lii, 4ey4, 4pqe, 5hq3 – hAChE - recombinant human
    
  • 1ea5, 2ace, 2j3d, 1w75, 2vt6, 2vt7 – TcAChE – Torpedo californica
    
  • 1qid, 1qie, 1qif, 1qig, 1qih, 1qii, 1qij, 1qik, 1qil, 1qim - TcAChE synchrotron radiation damage
    
  • 1vzj – TcAChE tetramerization domain
    
  • 1j06, 1maa, 5dti – mAChE - mouse
    
  • 6xys – DmAChE - Drosophila melanogaster
    
  • 1eea, 1c2b, 1c2o – AChE – Electric eel
    
  • 5x61, 5ydh, 5ydi – mmAChE – malaria mosquito
    
  • 6arx – mmAChE (mutant)
    
  • 6uqv – PaAChE – Pseudomonas aeruginosa
    
  • 6ur0 – PaAChE (mutant)
    
• AChE inhibitors (In Different Languages)
  • 1eve AChE-Aricept complex, 1eve (Arabic), 1eve (Chinese), 1eve (Italian), 1eve (Russian), 1eve (Spanish), 1eve (Turkish), 1eve (Italian), 1eve (Czech), 1eve (Catalan), 1eve (Slovak), 1eve (German), 1eve (Hebrew), 1eve (Vietnamese)
    
  • 1vot AChE-Huperzine A complex, 1vot (Chinese)
    
• Torpedo californica AChE active site inhibitors conjugating at the bottom of the active site gorge
  • 2c4h – TcAChE + acetylthiocholine
    
  • 5e4t, 5e2i, 5e4t, 5dlp, 5e4j, 5e4t – TcAChE + methylene blue
    
  • 2vq6 – TcAChE + 2-PAM
    
  • 2j3q – TcAChE + Thioflavin T
    
  • 1gpk, 1gpn, 1vot – TcAChE + huperzine
    
  • 1gqr, 6eue – TcAChE + rivastigmine
    
  • 1gqs – TcAChE + NAP
    
  • 1e66 – TcAChE + huprine
    
  • 6g1v – TcAChE + huprine derivative
    
  • 5ehx, 5ei5– TcAChE + MSF
    
  • 6g4m, 6g4n, 6g4o, 6g4p, 4tvk, 4w63, 4x3c, 6g1u, 6g1w, 6fqn, 6fld, 5nuu – TcAChE + tacrine derivative
    
  • 1oce – TcAChE + MF268
    
  • 1ax9, 2ack – TcAChE + edrophonium
    
  • 1amn – TcAChE + TMTFA
    
  • 1acj – TcAChE + tacrine
    
  • 4tvk, 4w63, 4x3c - TcAChE + tacrine hybrid
    
  • 5bwb, 5bwc - TcAChE + oxime derivative
    
  • 1u65 – TcAChE + CPT-11
    
  • 2bag - TcAChE + ganstigmine
    
  • 2xi4 - TcAChE + aflatoxin
    
  • 6f25, 6ezg, 6ezh, 6ewk, 6euc - TcAChE + inhibitor
    
• Mosquito AChE active site inhibitors conjugating at the bottom of the active site gorge
  • 2wls – mmAChE + AMTS13
    
  • 5ydj – mmAChE + PMSF
    
  • 6fsd, 6fse - mmAChE + inhibitor
    
  • 6ary - mmAChE (mutant) + inhibitor
    
• mouse AChE active site inhibitors conjugating at the bottom of the active site gorge
  • 2ha0 – mAChE + ketoamyltrimethylammonium
    
  • 2h9y – mAChE + TMTFA
    
  • 4bc0, 4bc1 – mAChE + CBDP
    
  • 4a16 – mAChE + huprine
    
  • 4ara, 4arb, 4a23, 4b7z, 4b80, 4b81, 4b82, 4b83, 4b84, 4b85, 4btl, 5fum, 5ehn, 5ehq, 5ehz, 5eia, 6td2, 7qak, 7qb4, 7qyn, 7r02 - mAChE + inhibitor
    
  • 2xuf, 2xug, 2xuh, 2xui, 2xuj, 2xuk, 2xuo, 2xup, 2xuq - mAChE (mutant) + inhibitor
    
• human AChE active site inhibitors conjugating at the bottom of the active site gorge
  • 4ey5 – hAChE + huperzine
    
  • 7e3i – hAChE + tacrine
    
  • 7e3h – hAChE + donepezil
    
  • 4m0e, 4m0f, 6wuv, 6wuz, 6wvc, 6wvp, 6wvq, 6xta, 6zwe, 7d9o, 7d9p, 7d9q, 7p1p - hAChE + inhibitor
    
  • 6o5v, 6o5s, 5o5r, 6u3p, 6u34, 6u37, 6nea - hAChE + oxime reactivator
    
  • 6o4x - hAChE + acridine derivative
    
  • 7p1n - hAChE + oxime derivative
    
• Drosophila melanogaster AChE active site inhibitors conjugating at the bottom of the active site gorge
  • 6xyy, 6xyu – DmAChE + tacrine derivative
    
• Other organisms AChE active site inhibitors
  • 6tt0 – AChE + inhibitor – Tetronarce californica
    
• AChE peripheral site inhibitors conjugating at the surface of the protein
  • 1b41, 1f8u, 4ey8 - hAChE + fasciculin 2
    
  • 2x8b - hAChE + fasciculin 2 + tabun
    
  • 4bdt - hAChE + fasciculin 2 + huprine W
    
  • 1ku6, 1mah - mAChE + fasciculin 2
    
  • 1j07 - mAChE + decidium
    
  • 1n5m - mAChE + gallamine
    
  • 1n5r - mAChE + propidium
    
  • 1fss - TcAChE + fasciculin 2
    
• AChE bis inhibitors spanning the active site gorge
  • 4ey6 - hAChE + galanthamine
    
  • 4ey7, 5nau, 5nap, 6o4w - hAChE + donepezil derivative
    
  • 6o50, 6o52 – hAChE + bw284c51
    
  • 1q83, 1q84, 5eie, 5eih - mAChE + TZ2 derivative
    
  • 5fkj - mAChE + uracil derivative
    
  • 5foq - mAChE + ligand
    
  • 3i6m, 3i6z, 1w4l, 1w6r, 1w76, 1dx6, 1qti – TcAChE + galanthamine derivative
    
  • 1zgb, 1zgc – TcAChE + tacrine (10) hupyridone
    
  • 2w6c – TcAChE + bis-(-)-nor-meptazinol
    
  • 2ckm, 2cmf – TcAChE + bis-tacrine
    
  • 1odc, 2cek, 1ut6, 6h13, 6h12, 6h14 - TcAChE + acridine derivative
    
  • 1h22, 1h23 – TcAChE + bis-hupyridone
    
  • 1hbj, 7ais, 7ait, 7aiu, 7aiv, 7aiw, 7aix – TcAChE + quinoline derivativev
    
  • 1e3q – TcAChE + bw284c51
    
  • 1eve – TcAChE + e2020
    
  • 1acl – TcAChE + decamethonium
    
  • 2xud – TcAChE (mutant) + decamethonium
    
  • 3zv7 - TcAChE + bisnorcymserine
    
• AChE organophosphate inhibitors causing irreversible inhibition
  • 6cqt, 6cqx, 6cqz - hAChE + VX
    
  • 5fpq - hAChE + sarin
    
  • 6cqu – hAChE + HI-6
    
  • 6cqv, 2cqw – hAChE + HI-6 + VX
    
  • 6cqy – hAChE + HI-6 + EMPA
    
  • 6wuy – hAChE + HI-6 + GA
    
  • 6wv1 – hAChE + HI-6 + GB
    
  • 5hf6, 5hf8, 5hf5 – hAChE (mutant) + paraoxon
    
  • 5hfa – hAChE + paraoxon + 2-PAM
    
  • 5hf9 – hAChE + paraoxon + HI6
    
  • 2wu3 – mAChE + fenamiphos and HI-6
    
  • 2wu4 – mAChE + fenamiphos and ortho-7
    
  • 2jgf - mAChE + fenamiphos
    
  • 2whp, 2whq, 2whr, 5fpp – mAChE + sarin and HI-6
    
  • 2y2v - mAChE + sarin
    
  • 3zlu – mAChE + cyclosarin
    
  • 2jgl - mAChE + VX + sarin
    
  • 7r0a – mAChE + sarin + HI-6
    
  • 3dl4, 3dl7, 2c0p, 2c0q – mAChE + tabun
    
  • 2jey – mAChE + HLO-7
    
  • 2jez - mAChE + tabun + HLO-7
    
  • 2jf0 - mAChE + tabun + Ortho-7
    
  • 3zlv – mAChE + tabun + HI-6
    
  • 7r2f – mAChE + tabun + inhibitor
    
  • 2y2u - mAChE + VX
    
  • 7r3c - mAChE + VX + inhibitor
    
  • 2jgi, 2jgm, 5hcu - mAChE + DFP
    
  • 5dtj – mAChE + DFP + SP-134
    
  • 2jgj, 2jgk, 2jge - mAChE + methamidophos
    
  • 2gyu - mAChE + HI-6
    
  • 2gyv - mAChE + Ortho-7
    
  • 2gyw - mAChE + obidoxime
    
  • 3zlt – mAChE + RVX
    
  • 7r4e - mAChE + RVX + inhibitor
    
  • 2wfz, 2wg0, 2wg2, 1som - TcAChE + soman
    
  • 2wg1 - TcAChE + soman + 2-PAM
    
  • 1cfj - TcAChE + sarin, GB
    
  • 6g17 – TcAChE + tabun
    
  • 1vxo, 1vxr, 6cqt - TcAChE + VX
    
  • 1dfp - TcAChE + DFP
    
  • 3gel - TcAChE + methyl paraoxon
    
  • 2dfp – TcAChE aged
    
• AChE substrate analogues mimicking the binding of the substrate acetylcholine
  • 7rb5, 7rb6 - hAChE + substrate analog
    
  • 7rb7 - hAChE + oxime derivative + substrate analog
    
  • 2ha4 – mAChE (mutant) + acetylcholine
    
  • 2ha2 – mAChE + succinylcholine
    
  • 2ha3 - mAChE + choline
    
  • 2ha5 – mAChE (mutant) + acetylthiocholine
    
  • 2ha6 – mAChE (mutant) + succinylthiocholine
    
  • 2ha7 – mAChE (mutant) + butyrylthiocholine
    
  • 2vja, 2vjb, 2vjc, 2vjd, 2cf5 – TcAChE + 4-oxo-N,N,N-trimethylpentanaminium
  • 2v96, 2v97, 2v98, 2v99 – TcAChE + 1-(2-nitrophenyl)-2,2,2-trifluoroethyl-arsenocholine
    
  • 2ch4, 2c58 – TcAChE + acetylthiocholine
    
  • 2c5g – TcAChE + thiocholine
    
  • 2c5f – TcAChE + substrate analog
    
  • 2va9 - TcAChE + ‘caged’ arsenocholine
    
  • 6ur1, 6uqz, 6uqw, 6uqy, 6uqx – PaAChE (mutant) + thiocholine derivative
    
• Others...
  • 2j4f – TcAChE + Hg
    
  • 7b2w – TcAChE + UO2
    
  • 7b8e – TcAChE + Ca
    
  • 7b38 – TcAChE + Mg
    
  • 1jjb – TcAChE + PEG
    
  • 3m3d – TcAChE + Xe
    
  • 5ih7 – TcAChE + methyl-dihydro-indole
    
  • 5ov9 – mAChE + crystal violet
    
  • 4qww – AChE + antibody – banded krait